Dengue Literature Review

Cambodia

2 min read

Cambodia

Overview

Cambodia is a dengue-endemic country in Southeast Asia with year-round transmission driven by Aedes aegypti and Aedes albopictus mosquitoes. Dengue is a leading cause of paediatric hospitalisation. The Institut Pasteur du Cambodge (IPC) in Phnom Penh serves as the national reference centre for arboviral diseases including dengue and has conducted prospective cohort studies in Kampong Cham province that have been the basis for several published dengue research papers. Cambodia is classified as hyperendemic with all four DENV serotypes circulating, and DENV-1 has been the dominant serotype in documented research cohorts from the 2012–2013 period.

Key Points from Literature

Cohort characteristics (Kampong Cham 2012–2013)

Vo2020 - Autoantibody Profiling in Dengue sampled Cambodian children from three hospitals in Kampong Cham City and district hospitals during June–October 2012 and 2013:

  • DENV-1 dominant: 72.7% of ASD, 76.9% of DF, and 87.5% of DHF patients infected with DENV-1
  • DENV-2 and DENV-4 present as minority serotypes
  • Hospitalised patients admitted at 3 ± 2 days after fever onset; classified as DF (n=13) or DHF (n=8) by WHO 1997 criteria
  • Asymptomatic individuals identified via household cluster investigation around confirmed hospitalised cases — a methodologically robust design for capturing true asymptomatic DENV infection
  • All 8 DHF patients were secondary infection; no primary-infection DHF observed in this cohort
  • Viral load was significantly higher in DHF (6.21×10⁴ copies/mL) than ASD (1.17×10³ copies/mL, p=0.02)

Contradictions & Debates

  • The single published study from Cambodia in this wiki (Vo2020) covers autoantibody profiling only; no epidemiological survey of serotype distribution or incidence over time is currently represented.

Sources

Graph View

Backlinks