Dengue Literature Review

log

31 min read

Wiki Operation Log

[2026-04-14] lint | health check

Errors fixed:

  • wiki/index.md — section header Sources (19) corrected to Sources (20); Geography (5) corrected to Geography (6); Autoimmunity in Dengue | 15 corrected to 16; Secondary Dengue Infection | 5 corrected to 6; IgM-IgG Serology ELISA | 2 corrected to 3
  • wiki/concepts/Antibody-Dependent Enhancement.md — frontmatter sources: 6 corrected to sources: 7; updated: corrected to 2026-04-14 (Bos2025 was added to content during ingest but frontmatter was not updated)
  • wiki/concepts/Autoimmunity in Dengue.md — Seet2007 moved from Related Pages to Sources (data is directly cited in body text; sources 15→16); frontmatter updated
  • wiki/concepts/Secondary Dengue Infection.md — Bos2025 section added (primary vs. secondary kinetics comparison; compressed/attenuated secondary responses); sources 5→6
  • wiki/methods/IgM-IgG Serology ELISA.md — Bos2025 added as source for isotype-specific ELISA measurements; sources 2→3

Flagged (not fixed):

  • ELISA Inhibition Method page: Bos2025 source page attributes this method to Bos2025, but the wiki page describes a specific Vazquez 2003 yellow-fever-adapted protocol; cannot verify from wiki whether Bos2025 used identical method — see raw PDF to confirm
  • Reading Plan - ANA and Dengue Dynamics only linked from index.md — sparse connectivity but acceptable for meta document
  • raw/Jhonson2022.pdf — filename typo (should be Johnson); link resolves correctly; raw/ is immutable

Watch items updated in state.md: stale thin-page alerts for DENV-1/DENV-3/E Protein corrected; new flags added for ELISA attribution, reading plan orphan, raw filename.

[2026-04-14] ingest | Bos 2025 - Longitudinal Antibody Dynamics After Dengue (PREPRINT)

Created:

  • wiki/sources/Bos2025 - Longitudinal Antibody Dynamics After Dengue.md
  • wiki/geography/Nicaragua.md (new geography page — HIMJR Managua pediatric cohort)

Updated:

  • wiki/concepts/Cross-Reactive Antibodies.md — new “Longitudinal kinetics” section: XR E-IgG rising 6–18M post-primary (t½=−2.13y); NS1-IgG waning (t½≈2.1y); EDI/II vs EDIII domain specificity; IgA/IgM/IgG3/IgG4 persistence at 18M; new Contradictions entry (rising XR vs. classical waning model); Sources updated; sources 5→6
  • wiki/entities/E Protein.md — new longitudinal kinetics section: XR E-IgG rise 6–18M; EDI/II as driver; EDIII flat; ADE implication; Sources 2→3
  • wiki/entities/NS1 Protein.md — new NS1-IgG waning kinetics section: t½≈2.1y; type-specific; autoimmunity thread context (NS1-mimicry component declines with NS1-IgG); Sources 4→5
  • wiki/concepts/Antibody-Dependent Enhancement.md — new “Rising XR E-IgG” section: challenge to classical waning model; EDI/II specificity; IgG3 persistence; new Contradictions entry; Sources 6→7
  • wiki/analyses/Notable Findings.md — new entry: XR E-IgG rises in ADE window; challenges classical waning model; NS1-IgG waning bridges acute ANA spike and 2-year ANA; sources 11→12
  • wiki/index.md — Bos2025 added to Sources table and citation-ranked table; Nicaragua added to Geography; E Protein 2→3; NS1 Protein 4→5; Cross-Reactive Antibodies 5→6; ADE 6→7; Geography 5→6; total pages 73→75; sources 19→20

Citation counts (retrieved 2026-04-14): SS 0 / CR 0 (preprint — expected)

Notable Findings: 1 entry added — rising XR EDI/II E-IgG challenges classical waning ADE model; NS1-IgG waning (t½≈2.1y) provides kinetic anchor for NS1-mimicry component of ANA trajectory.

[2026-04-13] ingest | Bruhns 2009 - FcγR Specificity and Affinity for IgG Subclasses

Created:

  • wiki/sources/Bruhns2009 - FcγR Specificity and Affinity for IgG Subclasses.md
  • wiki/methods/Surface Plasmon Resonance.md (new method page)

Updated:

  • wiki/entities/FcγRIIa Receptor.md — Overview corrected (old claim that HH binds IgG1/IgG3 with lower affinity was wrong; Bruhns shows H131 binds IgG1 ~1.5× more than R131, IgG3 identically; principal difference is IgG2, 4.5×); new affinity table section added; Contradictions expanded with mechanism revision; Sources 3→4
  • wiki/concepts/Antibody-Dependent Enhancement.md — new “FcγR Affinity Hierarchy” section added with Bruhns affinity values and dengue-specific interpretation; Contradictions updated; Related Pages + Sources updated; sources 5→6
  • wiki/analyses/Notable Findings.md — new entry: H131/R131 effect is IgG2-specific; FcγRIIB inhibitory weakness quantified; conventional IgG1-clearance model unsupported; sources 10→11
  • wiki/index.md — Bruhns2009 added to Sources table; citation-ranked table updated (1444 SS — now highest cited source in wiki); Methods 11→12; FcγRIIa 3→4; ADE 5→6; total pages 71→73

Citation counts (retrieved 2026-04-13): SS 1444 / CR 1303

Notable Findings: 1 entry added — FcγRIIa H131/R131 asymmetry is IgG2-specific; FcγRIIB affinity weakness quantified; both challenge the conventional IC-clearance model invoked in dengue.

[2026-04-13] ingest | Li 2018 - Increased Risk of Autoimmune Diseases in Dengue

Created:

  • wiki/sources/Li2018 - Increased Risk of Autoimmune Diseases in Dengue.md

Updated:

  • wiki/concepts/Autoimmunity in Dengue.md — “Population-Level Autoimmune Disease Risk After Dengue” section expanded: Li2018 NHIRD cohort fully documented (aHR 1.88 overall; primary adrenocortical insufficiency n=19, aHR 2.05; ADEM aHR 3.80; GBS non-significant; TLR/adrenocortical mechanism); cross-study ADEM/GBS convergence with Shih2023 noted; Li2018 added to Sources list; sources 14→15
  • wiki/geography/Taiwan.md — Li2018 NHIRD cohort section added; Contradictions section updated with ICD-coded vs. lab-confirmed methodological contrast; Related Pages and Sources updated; sources 2→3
  • wiki/analyses/Notable Findings.md — new entry: ADEM cross-design convergence (Li2018 aHR 3.80, Shih2023 aHR 2.72) as most methodologically robust disease-specific finding; GBS null convergence noted; adrenocortical TLR mechanism flagged as unvalidated but novel; sources 9→10
  • wiki/index.md — Li2018 added to Sources table; citation-ranked table updated; Autoimmunity in Dengue 14→15; Taiwan 2→3; total pages 70→71

Citation counts (retrieved 2026-04-13): SS 38 / CR 40

Notable Findings: 1 entry added — ADEM as the cross-design convergent finding (Li2018 × Shih2023); GBS null also convergent; adrenocortical TLR mechanism novel to wiki.

[2026-04-13] ingest | Seet 2007 - Post-Infectious Fatigue Syndrome in Dengue

Created:

  • wiki/sources/Seet2007 - Post-Infectious Fatigue Syndrome in Dengue.md
  • wiki/geography/Singapore.md (new geography page)

Updated:

  • wiki/concepts/Post-Dengue Syndrome.md — major addition: Seet2007 section with 24.4% fatigue rate, risk factor table, cross-cohort comparison table with Garcia2009; Contradictions expanded; Related Pages added Singapore and DENV-1; Sources updated (3→4)
  • wiki/concepts/Autoimmunity in Dengue.md — new subsection: indirect evidence on sex-bias and severity-independence convergence with Garcia2009; Related Pages added Singapore and Seet2007 cross-reference; sources count unchanged (14, indirect link only)
  • wiki/entities/DENV-1.md — Singapore 2005 outbreak section added (DEN-1 dominant, 20/27 typed); sources 1→2
  • wiki/entities/DENV-3.md — Singapore 2005 section added (DEN-3 minor serotype, 6/27); sources 2→3
  • wiki/methods/IgM-IgG Serology ELISA.md — Seet2007 added as source (double-sandwich capture ELISA, Innis 1989 protocol); sources 1→2
  • wiki/methods/RT-PCR.md — Seet2007 added as source (Lanciotti 1992 nested PCR for serotyping); sources 1→2
  • wiki/index.md — Seet2007 added to Sources table; Singapore added to Geography; counts updated throughout; total pages 68→70

Citation counts (retrieved 2026-04-13): SS 140 / CR 126

Notable Findings: No entry added — findings are directionally consistent with existing wiki content (severity-independence replicated; sex-bias confirmed); nothing rises to the “surprising given existing wiki” bar.

[2026-04-14] infra | Citation counts in index + web workflow + commands.md

Updated:

  • wiki/index.md — added Citations (SS / CR) column to Sources table; added ranked-by-citation subsection
  • wiki/commands.md — new meta page; reference for all curator commands and terminal commands (build, preview, Cloudflare tunnel on port 1330)
  • wiki/index.md — Meta section expanded to include commands.md; page count updated to 68
  • webforshare/quartz.config.ts — baseUrl updated from localhost:8080 to localhost:1330
  • webforshare/HOW-TO-BUILD.md — port updated; Cloudflare tunnel section added
  • webforshare/sync-and-build.ps1 — wiki source path corrected for new webforshare location (../dengue-wiki/wiki)
  • CLAUDE.md — added update web workflow

[2026-04-13] lint | Health check + structural fixes + new concept pages

Lint findings (summary):

  • 0 broken wikilinks in content pages
  • 0 orphan pages
  • 2 source count discrepancies (fixed below)
  • 17 thin pages (sources ⇐ 1)
  • 3 missing concept pages from CLAUDE.md domain context (2 created below; Herd Immunity deferred — no sources address it directly)
  • Geography gaps persist: only 4 countries, no regional pages

Fixed:

  1. wiki/index.md: Infection-Triggered Autoimmunity source count 5 → 6 (matched frontmatter)
  2. wiki/index.md: Dengue Pathophysiology source count 1 → 2 (matched inline citation of Lin2006)
  3. wiki/concepts/Dengue Pathophysiology.md: added [[Lin2006]] to Sources section; updated frontmatter sources: 2

Created:

  • wiki/concepts/Cross-Reactive Antibodies.md — synthesises cross-reactive Ab biology across 5 sources (Guzman2016, Sungnak2025, Garcia2010, Lin2006, Lin2011); covers neutralising vs. enhancing threshold, isotype divergence (IgG1 vs. IgA), broadly neutralising Abs, CYD-TDV proof-of-concept, diagnostic cross-reactivity
  • wiki/concepts/Cytokine Storm.md — synthesises cytokine-mediated pathogenesis across 4 sources (Sungnak2025, Wan2012, Guzman2016, Johnson2022); covers IL-10/TNF-alpha/IFN-alpha roles, NS1-TLR4 trigger, bystander activation, OAS amplification, temporal dynamics

Updated:

  • wiki/index.md — added 2 new concept pages; updated concept count to 19; updated total page count to 67
  • wiki/concepts/Antibody-Dependent Enhancement.md — added Related Pages links to Cross-Reactive Antibodies, Cytokine Storm
  • wiki/concepts/Dengue Pathophysiology.md — added Related Pages links to Cytokine Storm, Cross-Reactive Antibodies
  • wiki/concepts/Secondary Dengue Infection.md — added Related Pages links to Cross-Reactive Antibodies, Cytokine Storm
  • wiki/concepts/NS1 Molecular Mimicry in Dengue.md — added Related Pages links to Cross-Reactive Antibodies, Cytokine Storm

[2026-04-13] infra | Quartz static site setup in webforshare/

Created:

  • webforshare/ — Quartz v4 clone, configured as a static site for the wiki
  • webforshare/content/ — full mirror of wiki/ (synced via cp)
  • webforshare/sync-and-build.ps1 — script to re-sync wiki → content and rebuild the site
  • webforshare/HOW-TO-BUILD.md — setup and rebuild instructions for curator and colleagues

Pending:

  • npm install inside webforshare/ (requires Node.js LTS, install via winget install OpenJS.NodeJS.LTS)
  • Hosting provider TBD; baseUrl in quartz.config.ts will be updated once chosen

[2026-04-13] analysis | Wiki State and Gap Analysis 2026-04-13 + Notable Findings update

Created:

  • wiki/analyses/Wiki State and Gap Analysis 2026-04-13.md — full state audit at 16 sources/65 pages; gap map against 2026-04-12 baseline; ANA thread status table; 6-priority ingest order; documents which 2026-04-12 priorities were addressed and which remain open

Updated:

  • wiki/analyses/Notable Findings.md — added new entry: “NS1 molecular mimicry cannot explain the nuclear ANA — epitope spreading is the implied mechanism” (cross-cutting inference spanning Lin2006, Lin2011, Wan2012, Chatterjee2024, Johnson2022; visible only from synthesis)
  • wiki/index.md — added new gap analysis; updated analyses count to 5; updated page count to 65

[2026-04-13] analysis | ANA and Dengue — A Literature Review

Created:

  • wiki/analyses/ANA and Dengue - A Literature Review.md — comprehensive synthesis of ANA dynamics in dengue across 15 sources; covers healthy-population baselines, acute dengue ANA (Chatterjee2024), generic viral-infection comparator (Berlin2007), three mechanistic pathways (molecular mimicry, bystander activation, epitope spreading), post-dengue persistence (Garcia2009), clinical outcome constraints (Shih2023), host modifiers (FcγRIIa, sex, prior infection), and 6 key open questions.

Updated:

  • wiki/index.md — added analysis page entry; updated page count to 64

[2026-04-13] schema | Added state.md and workflow updates

Created:

  • wiki/state.md — persistent session context file tracking current focus, paper queue, structural decisions with rationale, and watch items

Updated:

  • CLAUDE.md — added state.md to architecture diagram; added Session Start and Session End workflows; added state.md update steps to Ingest (step 12) and Lint (step 4) workflows; added proactive query compounding to Query workflow (step 5)
  • wiki/index.md — added Meta section with state.md entry; updated page count to 63

Rationale: Inspired by Karpathy’s LLM Wiki pattern (gist) and a community comment on .brain folders. Addresses context loss between sessions — priorities, queued work, structural decisions, and known issues now persist in a single file that every new session reads first.

[2026-04-12] ingest | Chatterjee2024 - ANA Detection in Dengue Kolkata

Created (3 pages):

  • wiki/sources/Chatterjee2024 - ANA Detection in Dengue Kolkata.md (Chatterjee RP et al.; Virulence 2024; 135 lab-confirmed dengue patients; HEp-2 IIFA 54.8% vs. 10.3% controls; LIA 18.5%; MCTD and myositis significant; Kolkata India; doi:10.1080/21505594.2024.2400553)
  • wiki/geography/India.md (new geography page; Kolkata hospital-based setting; endemic dengue context; 1997 WHO classification; predominantly IgM-confirmed cohort; endemic vs. epidemic distinctions)
  • wiki/methods/Line Immunoassay ANA.md (new method page; LIA principle; 18 specific IgG autoantibody targets; IMTEC-ANA-LIA-XL; confirmatory test after IIFA; DFS70 exclusion marker; IIFA→LIA confirmation gap in dengue; disease association categorisation)

Updated (6 pages):

  • wiki/concepts/Antinuclear Antibodies.md — added Acute Dengue HEp-2 Gold Standard Data section (54.8% IIFA, 18.5% LIA, ~3:1 ratio); added Comparing ANA Rates Across Dengue Contexts table (Chatterjee2024/Berlin2007/Garcia2009 comparison); added Line Immunoassay ANA and India to Related Pages; added Chatterjee2024 to Sources. Sources 7→8.
  • wiki/concepts/Autoimmunity in Dengue.md — added ANA in Acute Dengue section (Chatterjee2024 rates; MCTD/myositis findings with caveats); added MCTD/myositis vs. Shih2023 ADEM contradiction to Contradictions section; added India and Line Immunoassay ANA to Related Pages; added Chatterjee2024 to Sources. Sources 12→13.
  • wiki/methods/Indirect Immunofluorescence ANA Test.md — added HEp-2 IIFA in Acute Dengue section (54.8% rate; IIFA→LIA gap; Immunoconcepts HEp-2000® kit); added Line Immunoassay ANA to Related Pages; added Chatterjee2024 to Sources. Sources 5→6.
  • wiki/analyses/Notable Findings.md — added entry: “Dengue drives a massive acute ANA spike (55% by HEp-2 IIFA) — but two-thirds are non-specific” — the IIFA:LIA ratio reveals the scale and non-specificity of dengue-induced nuclear autoimmunity. Sources 7→8.
  • wiki/index.md — added Chatterjee2024 source; added India geography; added Line Immunoassay ANA method; updated source count 14→15; updated concept/method/geography counts; updated total pages 60→66.
  • wiki/log.md — this entry

Context: Chatterjee2024 is the first paper in the wiki to measure ANA in acute dengue using the gold-standard HEp-2 IIFA platform. Its most important contribution is not the absolute 54.8% rate (which is setting-specific and partly reflects HEp-2 sensitivity) but the IIFA→LIA gap: only ~34% of IIFA-positive dengue patients confirmed by LIA. This quantifies for the first time what the mechanistic literature suggested — dengue massively perturbs non-specific nuclear autoimmunity, but very little of this corresponds to the targeted specificities of established systemic autoimmune diseases. This is coherent with Shih2023’s population-level null finding.

The MCTD/myositis signal is the paper’s other key contribution. It diverges from Shih2023’s ADEM signal, raising the possibility that dengue may have multiple narrow autoimmune sequelae (neurological → ADEM; rheumatological → MCTD/myositis) that appear in different study populations/settings. Both signals are hypothesis-generating rather than confirmed: Shih2023 is large but may lack power for rare rheumatological outcomes; Chatterjee2024 has wide CIs and a hospital-enriched sample. A definitive study would need Shih2023-scale population coverage with LIA-based outcome ascertainment.

Key cross-wiki connections:

  • The 54.8% HEp-2 rate provides the missing platform-matched comparator for Garcia2009 (rat liver, 2 years) — substrate gap remains unresolvable but the magnitude difference is now quantified
  • DFS70 exclusion marker methodology is now documented in the LIA method page — relevant to future ANA interpretation across all wiki sources
  • The India geography page establishes that endemic-area hospital-based studies and non-endemic population-based studies may genuinely detect different autoimmune disease associations after dengue

[2026-04-12] ingest | Shih2023 - Autoimmune Disease Risk After Dengue

Created (3 pages):

  • wiki/sources/Shih2023 - Autoimmune Disease Risk After Dengue.md (Shih H-I et al.; PLoS Negl Trop Dis 2023; 63,814 lab-confirmed dengue patients; Taiwan NHIRD+NDDCC; only ADEM elevated after dengue; doi:10.1371/journal.pntd.0011127)
  • wiki/geography/Taiwan.md (new geography page; NHIRD coverage; epidemic history 2002–2015; 2014–2015 57K+ cases; NS1 RDT rollout 2015; NDDCC lab-confirmation system; 51.4% pre-2015 misclassification rate)
  • wiki/concepts/Dengue Neurological Complications.md (new concept page; three neuropathogenesis pathways: encephalopathy/encephalitis/autoimmune; ADEM population-level risk [aHR 2.72, first month only]; GBS non-significant; DENV-2/3 CNS tropism; cross-flavivirus comparison)

Updated (9 pages):

  • wiki/concepts/Autoimmunity in Dengue.md — added Population-Level Autoimmune Disease Risk section (Shih2023: only ADEM survives Bonferroni; 51.4% misclassification in Li et al.); added new contradiction (Garcia2009 ANA elevation vs. Shih2023 no clinical disease); added Dengue Neurological Complications and Taiwan to Related Pages; added Shih2023 to Sources. Sources 11→12.
  • wiki/concepts/Infection-Triggered Autoimmunity.md — added Population-Level Constraint section (Shih2023 ADEM finding; transient autoimmunity support); added biomarker-vs-disease contradiction; added Dengue Neurological Complications to Related Pages; added Shih2023 to Sources. Sources 5→6.
  • wiki/concepts/Post-Dengue Syndrome.md — added Shih2023 section (ADEM only; autoimmune disease incidence not elevated long-term; Garcia2009 reconciliation); expanded Contradictions; added Dengue Neurological Complications and Taiwan to Related Pages; added Shih2023 to Sources. Sources 2→3.
  • wiki/entities/DENV-2.md — added CNS Tropism and Neuropathogenesis section; added Dengue Neurological Complications to Related Pages; added Shih2023 to Sources. Sources 1→2.
  • wiki/entities/DENV-3.md — added CNS Tropism and Neuropathogenesis section; added Dengue Neurological Complications to Related Pages; added Shih2023 to Sources. Sources 1→2.
  • wiki/methods/NS1 Antigen Detection.md — added Epidemiological Impact section (51.4% pre-2015 confirmation gap; 2015 RDT rollout; methodological implications for clinical dengue cohorts); added Shih2023 to Sources. Sources 2→3.
  • wiki/analyses/Notable Findings.md — added entry: “The prior ‘dengue causes broad autoimmune disease’ claim is largely an artifact of misclassification” — Shih2023 refutes Li et al. 2018 using 5× larger lab-confirmed cohort; 51.4% diagnostic accuracy problem has broad methodological implications. Sources 6→7.
  • wiki/index.md — added Shih2023 source; added Dengue Neurological Complications concept; added Taiwan geography; updated source count 13→14; updated entity/concept/geography counts; updated total pages 55→60.
  • wiki/log.md — this entry

Context: Shih2023 is methodologically the strongest paper ingested so far for the autoimmunity thread. It uses a larger, lab-confirmed cohort than any prior epidemiological study of post-dengue autoimmune disease, addresses multiple comparison problems explicitly (Bonferroni + Benjamini–Hochberg), and covers both inpatient and outpatient dengue. Its primary finding — that only ADEM is elevated after dengue, and only in the first month — substantially constrains the “dengue causes chronic autoimmunity” narrative that was supported primarily by case reports, the Garcia2009 Cuban cohort (autoimmune markers but not clinical diseases), and the Li et al. clinical cohort (shown here to have 51.4% misclassification). The Garcia2009 data (elevated ANA, IC, CRP at 2 years) remains unexplained by the Shih2023 population-level data, creating a productive new contradiction: biological autoimmune activation does not reliably produce clinical autoimmune disease.

Key cross-wiki connections:

  • Shih2023’s ADEM finding is directly consistent with the three-pathway neuropathogenesis model (Guzman2016 + Shih2023) — a new Dengue Neurological Complications page consolidates this content
  • DENV-2 and DENV-3 CNS tropism is now documented on those entity pages
  • The 51.4% misclassification rate contextualises NS1 Antigen Detection as epidemiologically transformative, not just diagnostically useful
  • The notable finding entry extends the methodological lesson beyond dengue: clinical-diagnosis-only cohorts for post-infectious autoimmunity may systematically overestimate risk

[2026-04-12] ingest | Guzman2016 - Dengue Infection (Nature Reviews Disease Primers)

Created (16 pages):

  • wiki/sources/Guzman2016 - Dengue Infection.md (Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB; doi:10.1038/nrdp.2016.55; comprehensive dengue Primer)
  • wiki/entities/DENV-1.md (Cuban epidemic history; DENV1→DENV2 severity sequence; conditional virulence)
  • wiki/entities/DENV-2.md (Asian vs American genotype; 1981 first Americas DHF; PDK-53 backbone; Santiago 1997)
  • wiki/entities/DENV-3.md (displacement dynamics; Cuba 2001; Sri Lanka genotype changes)
  • wiki/entities/Aedes albopictus.md (secondary vector; Europe/USA sporadic transmission; broader breeding sites)
  • wiki/entities/CYD-TDV.md (ChimeriVax; phase III efficacy 56.5%/60.8%; 5× seronegative hospitalisation; approved 9–45 years; ADE mechanism)
  • wiki/entities/E Protein.md (DI/DII/DIII domains; 90 monomers; DIII receptor binding; DII fusion loop; WGNGCG coagulation homology)
  • wiki/entities/Wolbachia.md (wMel strain; cytoplasmic incompatibility spread; DENV replication suppression; field trials)
  • wiki/concepts/Viraemia.md (timing 24–48h pre-fever; 5–6 days; diagnostic test windows; sNS1 severity correlation secondary; asymptomatic transmission)
  • wiki/concepts/Dengue Pathophysiology.md (vascular permeability; NS1-TLR4; APTT strongest correlate; thrombocytopenia dual mechanism; coagulopathy; complement; liver Councilman bodies)
  • wiki/concepts/Dengue Clinical Classification.md (2009 WHO 3 categories + 3 phases; warning signs; 1997 vs 2009 debate; diagnosis timeline; Zika cross-reactivity)
  • wiki/concepts/Dengue Vaccine Candidates.md (challenge framing; CYD-TDV/DENVax/TV003/subunit/inactivated; Sungnak2025 NS-epitope T cell vaccine implications)
  • wiki/concepts/Original Antigenic Sin.md (cross-reactive T cell memory dominance; OAS in secondary dengue; Sungnak2025 exhaustion markers consistent)
  • wiki/methods/RT-PCR.md (DENV RNA detection; days 0–5; serotyping; qRT-PCR quantification; WHO tiered structure)
  • wiki/methods/NS1 Antigen Detection.md (sNS1 ELISA + RDT; day 1–day 5–9; sensitivity by serotype/parity; sNS1 as pathogenic effector; Zika complications)
  • wiki/methods/IgM-IgG Serology ELISA.md (MAC-ELISA; IgM from day 5–6; IgG seroconversion; primary vs secondary discrimination; Zika cross-reactivity)

Updated (11 pages):

  • wiki/entities/NS1 Protein.md — revised Overview (three structural forms); added Direct sNS1 pathogenic mechanisms section (TLR4, endothelial barrier, thrombin binding in vivo, glycocalyx shedding, APTT prolongation, diagnostic correlate); renamed Coagulation interference section to clarify antibody-mediated mechanism. Sources 2→3.
  • wiki/entities/Aedes aegypti.md — added Vector biology section (extrinsic/intrinsic incubation; lifetime infectivity; blood meal timing); added Vector control programmes section (Cuba 1981; Singapore; Wolbachia; SIT). Sources 4→5.
  • wiki/entities/FcγRIIa Receptor.md — added FCGR2A in broader host genetics landscape section (Table 2: HLA, IL-10, TNF, DCSIGN1, VDR). Sources 2→3.
  • wiki/entities/DENV-4.md — added DENV-4 in Cuban serial serotype introduction section; 2006 Havana containment; 1981 Americas DHF significance. Sources 2→3.
  • wiki/concepts/Antibody-Dependent Enhancement.md — added Conditional virulence section (primary infections subclinical; 3rd/4th mild; maternal antibody ADE; inter-infection interval risk; CYD-TDV clinical proof-of-concept; DI-DII broadly neutralising Abs). Sources 3→4.
  • wiki/concepts/NS1 Molecular Mimicry in Dengue.md — added Direct sNS1 mechanisms section (TLR4; thrombin binding; endothelial barrier; glycocalyx; APTT); clarified relationship with anti-NS1 autoantibody pathway. Sources 2→3.
  • wiki/concepts/Asymptomatic Dengue Infection.md — added Infection parity section (primary infections predominantly subclinical; 3rd/4th mild; Cuban 1981 overt:subclinical ratios; inverted U severity pattern). Sources 3→4.
  • wiki/concepts/Post-Dengue Syndrome.md — major expansion: added 6-month QoL data (weakness 27.6%, headache 14.8%, arthralgia 10.6%); neurological complications (encephalopathy, encephalitis, GBS, transitory Parkinsonism, maculopathy); renal (AKI, GN, HUS); haematological (HLH). Sources 1→2.
  • wiki/concepts/T Cell Responses in Dengue.md — added T cell biology from Guzman2016 section (NS protein epitope CD8; CD4 multifunctionality; OAS cross-reactive T cells; vaccine NS antigen implication). Sources 1→2.
  • wiki/concepts/Type I Interferon Response in Dengue.md — added IFN-β and bone marrow suppression section (early febrile phase; LCMV analogy; comparison with Sungnak2025 IFN-α2). Sources 1→2.
  • wiki/geography/Cuba.md — added 1997 Santiago DENV-2 epidemic (overt:subclinical; amino acid E protein change; month-by-month severity increase); Cuban vector control programme history (1981 launch; three pillars + space spraying; 30-year success; eventual failure); 2013 La Habana classification consensus (lethality decrease with 2009 WHO system). Sources 2→3.

Notable Findings added (1):

  • APTT as strongest laboratory correlate of vascular permeability — connecting NS1-thrombin binding to plasma leakage via a shared sNS1 effector mechanism; implications for APTT as a prognostic biomarker superior to platelet count

Updated:

  • wiki/analyses/Notable Findings.md — sources 5→6
  • wiki/index.md — Sources 12→13, Entities 4→11, Concepts 10→15, Methods 7→10, Cuba sources 2→3; Total pages 39→55
  • wiki/log.md — this entry

Context: Guzman2016 is a comprehensive dengue primer from five leading dengue researchers. It required new pages for 7 entities not previously in the wiki (DENV-1, DENV-2, DENV-3, Aedes albopictus, CYD-TDV, E Protein, Wolbachia), 5 new concepts central to dengue pathogenesis (Viraemia, Dengue Pathophysiology, Dengue Clinical Classification, Dengue Vaccine Candidates, Original Antigenic Sin), and 3 new method pages (RT-PCR, NS1 Antigen Detection, IgM/IgG Serology ELISA). The paper substantially deepens the wiki’s dengue-specific content, which had previously been sourced mainly from autoimmunity-focused papers (Lin group, Garcia group, Sungnak2025). Key additions: the conditional virulence framing of ADE; the NS1 dual-pathway model (direct sNS1 + anti-NS1 autoantibodies); the APTT-vascular permeability mechanistic convergence; the CYD-TDV seronegative safety signal as clinical ADE proof-of-concept; and the comprehensive 2009 WHO clinical classification system.

[2026-04-12] lint | Full wiki audit (post-Lin ingests)

Issues found and fixed (8 total):

Wrong page count in index (1):

  • index.md: Total pages header read “41” but filesystem contains 39 files (12 sources + 4 entities + 10 concepts + 7 methods + 2 geography + 2 analyses + index + log = 39). Corrected 41 → 39. Root cause: Lin2006/Lin2011 ingest log entry overcounted; adding 4 pages to a pre-ingest count of 37 (itself slightly off) yielded 41 instead of 39.

Missing source citations (3):

  • PRNT: Sungnak2025 used PRNT for primary/secondary infection classification in the DENFREE Thailand cohort (alongside HI assay), but was not listed as a source. Added. Sources 1→2; frontmatter updated; index PRNT sources 1→2.
  • Aedes aegypti: Lin2006, Lin2011, and Sungnak2025 all list [[Aedes aegypti]] in their Entities Mentioned sections but were not reflected in the entity page’s Sources list. Added all three. Sources 1→4; frontmatter updated; index Aedes aegypti sources 1→4.
  • Autoimmunity in Dengue: Sungnak2025 is cited inline in the body (negative autoantibody finding: 120-antigen panel showed no significant differences across severity groups) but was missing from the Sources list at the bottom. Added. Sources 10→11; index count 10→11.

Stale link annotation (1):

  • Wiki State and Gap Analysis 2026-04-12: Related Pages listed [[NS1 Protein]] *(page not yet created)*. NS1 Protein was created during the Lin2006/Lin2011 ingest on 2026-04-12. Updated note to reflect creation date.

Missing connections (3):

  • Thailand: Did not link to [[NK Cell Responses in Dengue]] or [[Type I Interferon Response in Dengue]] despite both being major findings from the DENFREE Thailand cohort (Sungnak2025). Added to Related Pages.
  • Asymptomatic Dengue Infection: Did not link to [[qRT-PCR]] despite qRT-PCR being the definitional method for identifying viremic asymptomatic dengue in Sungnak2025 (also already in Related Pages of qRT-PCR). Added to Related Pages.
  • Wiki State and Gap Analysis 2026-04-12 → Notable Findings: Notable Findings had no inbound links except from index.md (true orphan for analysis page). Added cross-link from the companion analysis page.

Thin pages still present (acceptable at current wiki size):

  • ELISA Inhibition Method (1 source), Post-Dengue Syndrome (1 source), T Cell Responses in Dengue (1 source), NK Cell Responses in Dengue (1 source), Type I Interferon Response in Dengue (1 source), Single-Cell RNA Sequencing (1 source), V(D)J Sequencing (1 source), qRT-PCR (1 source), Thailand (1 source) — all thin because the wiki contains limited sources for each topic. To be expanded as review grows.

Suggested gaps / future ingests:

  • A Bruhns et al. 2009 (Blood) ingest would resolve the flagged FcγRIIa/IgG1 binding contradiction in FcγRIIa Receptor and Antibody-Dependent Enhancement.
  • DENV-1, DENV-2, DENV-3 entity pages are missing; Sungnak2025 references all three serotypes but they lack pages (note: DENV-2 was absent from that cohort). These stubs could be created pre-emptively.
  • A second post-dengue cohort paper (e.g., Seet et al. 2007) would lift Post-Dengue Syndrome off its single-source dependency and allow geographic/serotype generalisation of the core claim.
  • The Aedes albopictus vector is mentioned in the CLAUDE.md domain context but has no page and no source that discusses it; not currently a gap given the autoimmunity focus but worth noting for future vector-biology expansion.

[2026-04-12] ingest | Lin2006 + Lin2011 — NS1 Molecular Mimicry Series (NCKU Taiwan)

Created (4 pages):

  • wiki/sources/Lin2006 - Autoimmune Pathogenesis in Dengue Virus Infection.md (review; anti-NS1 platelet IgM autoAbs; endothelial apoptosis + NF-κB inflammation; murine in vivo permeability and hepatitis-like effects; absorption experiments)
  • wiki/sources/Lin2011 - Molecular Mimicry Virus Host Dengue Pathogenesis.md (minireview; NS1 molecular targets: PDI/vimentin/HSP60/ATP synthase β; C-terminal NS1 aa 311–352; WGNGCG E protein coagulation motif; flavivirus comparison; anti-prM/HSP60; acute-phase autoimmunity timing; virus-autoimmune disease catalogue)
  • wiki/entities/NS1 Protein.md (new entity page; autoantigenic properties; C-terminal domain; platelet and endothelial targets; vaccine implications; IgM vs IgG anti-platelet debate)
  • wiki/concepts/NS1 Molecular Mimicry in Dengue.md (new concept page; synthesis of both Lin papers; platelet effects; endothelial apoptosis + inflammation pathways; anti-prM; WGNGCG motif; acute-phase timing; contradictions)

Updated (4 pages):

  • wiki/concepts/Autoimmunity in Dengue.md — added NS1 Molecular Mimicry section with both Lin papers (PDI/vimentin/HSP60/ATP synthase β targets, C-terminal domain, WGNGCG motif, acute-phase timing); updated tags, sources 8→10; added NS1 Molecular Mimicry in Dengue and NS1 Protein to Related Pages
  • wiki/concepts/Infection-Triggered Autoimmunity.md — added dengue NS1 as detailed molecular mimicry case study; added Lin2011 Table 1 virus-autoimmunity catalogue; updated tags, sources 3→5; added NS1 Molecular Mimicry in Dengue and NS1 Protein to Related Pages
  • wiki/index.md — added 2 new sources, 1 new entity, 1 new concept; updated totals to Sources: 12, Pages: 41
  • wiki/log.md — this entry

Context: These two NCKU Taiwan review papers directly fill the highest-priority gap identified in the 2026-04-12 wiki analysis: “Papers on dengue NS1 molecular mimicry (endothelial/platelet cross-reactivity) would directly connect Infection-Triggered Autoimmunity to dengue biology.” Lin2006 establishes the autoantibody correlates and functional mechanisms (platelet lysis, endothelial apoptosis + inflammation); Lin2011 resolves the molecular targets (PDI, vimentin, HSP60, ATP synthase β) and the responsible NS1 domain (C-terminal aa 311–352). Together they make NS1 molecular mimicry the best-evidenced mechanism for the haemorrhagic syndrome in DHF/DSS, and establish dengue as a distinctive case of acute-phase (rather than post-infectious) virus-induced autoimmunity.

Key cross-wiki connections reinforced:

  • Lin2006 anti-platelet IgM finding does not contradict Garcia2010 FcγRIIa/IgG findings — different isotypes, different phases/mechanisms
  • Lin2011 cites Garcia2009 (as Garcia G et al. 2011) for post-dengue autoimmune syndrome, confirming NCKU group awareness of the Cuban cohort data
  • WGNGCG flavivirus motif provides independent molecular support for haemorrhagic phenotype, complementing the NS1/platelet mechanism
  • C-terminal NS1 domain mapping has direct implications for NS1-based vaccine design (epitope exclusion required to avoid autoimmune risk)

[2026-04-12] ingest | Sungnak 2025 - Distinct Immune Responses Asymptomatic Symptomatic Dengue

Created (8 pages):

  • wiki/sources/Sungnak2025 - Distinct Immune Responses Asymptomatic Symptomatic Dengue.md
  • wiki/methods/Single-Cell RNA Sequencing.md (new method page; scRNA-seq workflow, CITE-seq reference mapping, limitations for dengue)
  • wiki/methods/V(D)J Sequencing.md (new method page; BCR/TCR repertoire, clonotype networks, IGHV4-3901 public clonotype)*
  • wiki/methods/qRT-PCR.md (new method page; dengue viremia quantification, role in asymptomatic dengue identification)
  • wiki/concepts/T Cell Responses in Dengue.md (new concept page; CD8 TEM effector vs. exhausted phenotypes, MAIT/iNKT, longitudinal clonal tracking)
  • wiki/concepts/NK Cell Responses in Dengue.md (new concept page; FcεRIγ phenotype, NKG2D/NKp46 activating receptors, CD94 inhibitory receptor, NKG2D-MICB genetics link)
  • wiki/concepts/Type I Interferon Response in Dengue.md (new concept page; IFN-α2 elevation in symptomatic dengue, ADE-IFN axis, pattern recognition receptors)
  • wiki/geography/Thailand.md (new geography page; DENFREE cohort sites, serotype distribution, institutional context)

Updated (4 pages):

  • wiki/concepts/Asymptomatic Dengue Infection.md — major expansion: added entire single-cell immune profiling section from Sungnak2025 (cell composition, MHC-I presentation signals, CD8 TEM effector profile, IGHA1+ plasmablasts, NK phenotype); updated tags, sources count 2→3, updated date; added new related pages (Thailand, T Cell Responses, NK Cell Responses, Type I IFN, scRNA-seq)
  • wiki/concepts/Antibody-Dependent Enhancement.md — added full section on transcriptomic ADE evidence (FcR/endocytosis pathway enrichment in DHF, IGHG1/IGHA1 isotype bias, public BCR clonotype, IL-10→plasmablast axis); updated tags, sources count 2→3, date; added contradictions note on correlational nature of transcriptomic evidence; added new related pages
  • wiki/index.md — added Sungnak2025 source, 3 new concepts, 3 new methods, 1 new geography; updated totals to Sources: 10, Pages: 37
  • wiki/log.md — this entry

Context: Sungnak2025 is a landmark paper — the first scRNA-seq study to include viremic asymptomatic dengue alongside symptomatic severity groups. It fundamentally advances the mechanistic understanding of protective vs. pathogenic immunity and is highly relevant to: (1) the asymptomatic dengue thread (protective immune correlates), (2) the ADE thread (transcriptomic evidence and IGHG1/IGHA1 isotype distinction), and (3) the autoimmunity thread (negative finding: no autoantibody differences between severity groups, no anti-IFN antibodies). The paper’s vaccine implications — supporting CD8 T cell-targeting strategies and nonstructural protein inclusion — connect to TAK-003/TV-003 vs. CYD-TDV comparisons.

[2026-04-12] analysis | Wiki State and Gap Analysis

Created (1 page):

  • wiki/analyses/Wiki State and Gap Analysis 2026-04-12.md

Updated (2 pages):

  • wiki/index.md — added Analyses section, updated total pages 27→28
  • wiki/log.md — this entry

Summary: Curator-directed synthesis capturing the current research thread (dengue-associated autoimmunity, ANA persistence post-DENV-4) and six identified gap areas with specific paper recommendations. Priority ingest order: NS1 molecular mimicry → second post-dengue cohort → Bruhns et al. → post-dengue GBS → diagnostics review.

[2026-04-11] ingest | Garcia 2009 - Long-term Clinical Symptoms Post-Dengue

Created (10 pages — first ingest, bootstrapping wiki):

  • wiki/sources/Garcia2009 - Long-term Clinical Symptoms Post-Dengue.md
  • wiki/entities/DENV-4.md
  • wiki/entities/FcγRIIa Receptor.md
  • wiki/concepts/Post-Dengue Syndrome.md (dedicated page, curator request)
  • wiki/concepts/Autoimmunity in Dengue.md
  • wiki/concepts/Antibody-Dependent Enhancement.md
  • wiki/methods/PRNT.md
  • wiki/methods/ELISA Inhibition Method.md
  • wiki/methods/FcγRIIa Genotyping.md
  • wiki/geography/Cuba.md
  • wiki/index.md (bootstrapped)
  • wiki/log.md (bootstrapped)

Updated: (none — first ingest)

[2026-04-12] ingest | ANA Prevalence Series (5 papers: Tan1997, Satoh2012, Li2019, Aringer2019, Dinse2022)

Created (7 pages):

  • wiki/sources/Tan1997 - ANA Range in Healthy Individuals.md
  • wiki/sources/Satoh2012 - ANA Prevalence in United States.md
  • wiki/sources/Li2019 - ANA Epidemiology in Chinese Healthy Population.md
  • wiki/sources/Aringer2019 - 2019 EULAR ACR SLE Classification Criteria.md
  • wiki/sources/Dinse2022 - Increasing ANA Prevalence in United States.md
  • wiki/concepts/Antinuclear Antibodies.md (new concept page; synthesises all 5 ANA papers + Garcia2009)
  • wiki/methods/Indirect Immunofluorescence ANA Test.md (new method page)

Updated (3 pages):

  • wiki/concepts/Autoimmunity in Dengue.md — added ANA contextualisation section with healthy-population comparators from all 5 ANA papers; updated sources count to 6
  • wiki/index.md — added 5 new sources, 1 new concept, 1 new method; updated total page count
  • wiki/log.md — this entry

Context: These 5 papers provide healthy-population ANA baselines (at dilutions 1:40, 1:80, 1:100, 1:160, 1:320; in international, US, and Chinese populations; spanning 1988–2012) to contextualise the 23.1% ANA positivity reported in Garcia2009’s post-dengue symptomatic cohort. The Dinse2022 paper notes an important publication history: originally published as art.41214 (2020), retracted due to NHANES data corrections by CDC (not author error), republished as art.42330 (2022); conclusions unchanged.

[2026-04-11] ingest | Garcia 2010 - Asymptomatic Dengue FcγRIIa Polymorphism

Created (3 pages):

  • wiki/sources/Garcia2010 - Asymptomatic Dengue FcγRIIa Polymorphism.md
  • wiki/concepts/Asymptomatic Dengue Infection.md (curator request)
  • wiki/entities/Aedes aegypti.md (stub; background mention)

Updated (6 pages):

  • wiki/entities/FcγRIIa Receptor.md — added quantitative genotype/allele data, RR protective ORs, Havana population frequencies, Bruhns mechanism contradiction
  • wiki/concepts/Antibody-Dependent Enhancement.md — added RR/HH mechanistic model and Bruhns et al. contradiction
  • wiki/geography/Cuba.md — expanded epidemic history detail, added Havana FcγRIIa population frequencies
  • wiki/entities/DENV-4.md — added Garcia2010 as second source using the same cohort
  • wiki/index.md — added new source, new concept, new entity; updated source counts
  • wiki/log.md — this entry

[2026-04-12] ingest | ANA in Viral Infections Series (2 papers: Berlin2007, Johnson2022)

Created (3 pages):

  • wiki/sources/Berlin2007 - Autoantibodies in Nonautoimmune Individuals during Infections.md
  • wiki/sources/Johnson2022 - Infectious Diseases Autoantibodies and Autoimmunity.md
  • wiki/concepts/Infection-Triggered Autoimmunity.md (new concept page; synthesises Berlin2007, Johnson2022, Garcia2009)

Updated (4 pages):

  • wiki/concepts/Autoimmunity in Dengue.md — added section on viral-infection-triggered ANA (Berlin2007), mechanistic framework (Johnson2022); sources count updated 6→8; added Infection-Triggered Autoimmunity to Related Pages
  • wiki/concepts/Antinuclear Antibodies.md — added section on ANA during acute infections (Berlin2007); sources count updated 6→7; added Infection-Triggered Autoimmunity to Related Pages
  • wiki/index.md — added 2 new sources, 1 new concept; updated totals to Sources: 9, Pages: 27
  • wiki/log.md — this entry

Context: Berlin2007 provides the critical cross-infection ANA comparator:

[2026-04-12] lint | Full wiki audit

Issues found and fixed (11 total):

Wrong links (3):

  • Berlin2007 Entities Mentioned: removed spurious [[Aedes aegypti]] link (that vector has no connection to this paper)
  • Berlin2007 Methods Used: removed incorrect [[ELISA Inhibition Method]] link (that page is for dengue IgG inhibition ELISA; Berlin2007 uses Euroimmun ANA 8 Pro ELISA — no equivalent method page exists yet)
  • Johnson2022 Methods Used: removed incorrect [[ELISA Inhibition Method]] link (review paper; no dengue serology methods)

Unlinked method (1):

  • Garcia2009 Methods Used: linked plain-text ANA method to [[Indirect Immunofluorescence ANA Test]]; added inline note about rat liver tissue substrate

Unflagged scientific contradiction — critical (1):

  • Garcia2009 uses rat liver tissue as the IIF substrate (older, less sensitive than HEp-2). All healthy-population reference studies use HEp-2. This means the 23.1% post-dengue ANA rate is an underestimate; had HEp-2 been used the rate would be higher. Flagged in: Indirect Immunofluorescence ANA Test (Contradictions), Autoimmunity in Dengue (Contradictions), Antinuclear Antibodies (ANA in Post-Dengue Context)

Thin method page (1):

  • FcγRIIa Genotyping: Garcia2010 uses the identical protocol but was not listed as a source; added finding summary and updated sources 1→2

Duplicate line (1):

  • Garcia2010: duplicate [[Antibody-Dependent Enhancement]] entry in Concepts Addressed removed

Missing connections (5):

  • Post-Dengue Syndrome: added [[Antinuclear Antibodies]] and [[Infection-Triggered Autoimmunity]] to Related Pages
  • DENV-4: added [[Autoimmunity in Dengue]] to Related Pages
  • Cuba: added [[Autoimmunity in Dengue]] to Related Pages
  • Antibody-Dependent Enhancement: added [[Infection-Triggered Autoimmunity]] to Related Pages
  • index.md: corrected ## Sources (7) → ## Sources (9) (heading was not updated after last ingest); corrected FcγRIIa Genotyping sources 1→2

Thin pages still present (acceptable at current wiki size):

  • PRNT (1 source), ELISA Inhibition Method (1 source), Post-Dengue Syndrome (1 source), Aedes aegypti (1 source, stub) — all thin because only 2 dengue-specific source papers have been ingested; to be filled as review expands

Suggested gaps / future ingests:

  • An ELISA page for specific-antigen ANA testing (e.g., ENA line blot, ELISA 8 Pro) would be needed to properly reference Berlin2007’s method
  • Post-dengue case series or prospective studies from other cohorts (non-Cuban, non-DENV-4) would resolve the thinness of Post-Dengue Syndrome
  • Papers on dengue NS1 molecular mimicry (endothelial/platelet cross-reactivity) would directly connect Infection-Triggered Autoimmunity to dengue biology 21.7% ANA positive during acute viral infections (HAV/HBV/HCV) vs. 3.8% healthy blood donor controls (ELISA, ANA 8 Pro, 1:100). This closely matches Garcia2009’s 23.1% post-dengue finding, raising the question of whether the dengue-associated elevation is a generic viral-infection phenomenon or dengue-specific. The transience evidence (20.5%→6.4% in acute vs. convalescent viral hepatitis) makes Garcia2009’s 2-year persistence more significant. Johnson2022 provides the mechanistic framework — molecular mimicry, bystander activation, epitope spreading — with the notable finding that bystander activation from severe viral illness (COVID-19) does not significantly elevate ANA, implicating dengue-specific mechanisms (NS1 mimicry, FcγRIIa-driven IC persistence) as more likely explanations for the Garcia2009 ANA finding.

[2026-04-12] lint | Wiki structure audit and cleanup

Issues found and fixed:

  1. Stray file removed: NS1 Protein.md at project root (empty duplicate of wiki/entities/NS1 Protein.md)
  2. Broken wikilinks fixed (5 occurrences): [[IgM/IgG Serology ELISA]] → [[IgM-IgG Serology ELISA]] in NS1 Antigen Detection, Guzman2016, RT-PCR, Dengue Clinical Classification, Viraemia
  3. Missing page created: [[Secondary Dengue Infection]] — concept page with 4 sources (Guzman2016, Garcia2010, Sungnak2025, Lin2006); was linked from IgM-IgG Serology ELISA but had no page
  4. Page count corrected: Index header said 66 pages; actual count is 60 (15 sources + 17 concepts + 11 entities + 11 methods + 4 geography + 2 analyses)

Thin pages (≤1 source) — expected at current wiki size:

  • Entities: DENV-1, Aedes albopictus, CYD-TDV, Wolbachia
  • Concepts: NK Cell Responses in Dengue, Dengue Pathophysiology, Dengue Clinical Classification, Original Antigenic Sin
  • Methods: ELISA Inhibition Method, Single-Cell RNA Sequencing, V(D)J Sequencing, qRT-PCR, RT-PCR, IgM-IgG Serology ELISA, Line Immunoassay ANA
  • Geography: Thailand, Taiwan, India

No orphan pages found. All pages have at least one inbound link. No stale cross-references found (after fixes above).

[2026-04-12] ingest | Wan2012 - Autoimmunity in Dengue Pathogenesis

Source: Wan SW et al. (2012) Autoimmunity in dengue pathogenesis. J Formos Med Assoc 112:3–11. DOI: 10.1016/j.jfma.2012.11.006 Citations: Semantic Scholar 92; CrossRef 77 (retrieved 2026-04-12)

Created:

  • wiki/sources/Wan2012 - Autoimmunity in Dengue Pathogenesis.md

Updated (7 pages):

  • NS1 Protein: added LYRIC mimicry, RGD structural mimicry, complement-mediated lysis protection; sources 3→4
  • NS1 Molecular Mimicry in Dengue: added LYRIC/RGD/capsid mimicry targets, autoantibody kinetics section; sources 3→4
  • Antibody-Dependent Enhancement: added intrinsic ADE section (IFN-I suppression, IL-10/Th2); sources 4→5
  • Autoimmunity in Dengue: added autoantibody kinetics/temporal profile, dengue→SLE case reports, intrinsic ADE–autoimmunity link; sources 13→14
  • Dengue Vaccine Candidates: added NS1 vaccine paradox section (protective + pathogenic); sources 2→3
  • Taiwan: added epidemic history, age distribution, seasonal pattern; sources 1→2
  • Secondary Dengue Infection: added Wan2012 as source; sources 4→5

Notable Findings: 1 entry added — intrinsic ADE as mechanistic link between viral enhancement and autoantibody production

Index: updated source count 15→16, total pages 61→62, source counts for 7 concept/entity pages

Graph View